TLR4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation
نویسندگان
چکیده
Department of Surgery, University of Pittsburgh, Pittsburgh, PA; Department of Anesthesiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou; Department of Anesthesiology,Shanghai Tenth People's Hospital, Tongji University,School of Medicine, Shanghai, P.R. China; Division of Pediatric Surgery, Department of Surgery, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh PA * indicates co-first authors / ** indicates co-senior authors
منابع مشابه
Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.
BACKGROUND Growing evidence indicates that the presence of toll-like receptor 4 (TLR4) on platelets is a key regulator of platelet number and function. Platelets exposed to TLR4 agonists may serve to activate other cells such as neutrophils and endothelial cells in sepsis and other inflammatory conditions. The functional significance of platelet TLR4 in hemorrhagic shock (HS), however, remains ...
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